Toxicity assessment of methanol extract of <i>Combretum micranthum</i> in <i>Drosophila melanogaster</i>

Combretum micranthum leaves have been used traditionally in West Africa to manage pyrexia, cough, bronchitis, diabetes, malaria and other related ailments. It has also demonstrated alleviate high blood pressure skin inflammation. Drosophila melanogaster gaining acceptability biomedical research because of homologs its genes present humans the relative cost using flies. The purpose study is investigate acute sub-acute toxicity melanogaster. were extracted 90%v/v methanol. extract was screened for presence phytochemicals, fruit Doses between 5- 100 mg/10 g diet while 0 (Control), 1.5, 3 6 study. phytochemical analysis revealed alkaloids, glycosides, saponins, flavonoids tannins. an LD50 26.42 diet. methanol no effect on weight flies (p<0.05) among different interventions. did not affect negative geotaxis ability irrespective dose. At diet, raised triglyceride trehalose levels when compared doses (p<0.05). Glucose glycogen groups. Overall, results indicated that at a dose mg/ 10 tolerable